Aerobic Ligand‐Free Suzuki Coupling Reaction of Aryl Chlorides Catalyzed by In Situ Generated Palladium Nanoparticles at Room Temperature

An aerobic, ligand‐free Suzuki coupling reaction catalyzed by in situ generated palladium nanoparticles in polyethylene glycol with an average molecular weight of 400 Da (PEG‐400) at room temperature has been developed. This catalytic system is a very simple and highly active protocol for the Suzuki coupling of aryl chlorides with arylboronic acids, which proceed smoothly in excellent yields in short times using low catalyst loadings. Control experiments demonstrated that the Suzuki reaction catalyzed by the in situ generated palladium nanoparticles can be carried out much quicker than that using the preprepared particles under the same conditions. The formation of palladium nanoparticles in PEG‐400 was promoted by arylboronic acids.