High-Throughput Screening Studies of Fiber-Supported Catalysts Leading to Room-Temperature Suzuki Coupling

High-throughput screening of triphenylphosphine-based polymer-supported homogeneous catalysts (e.g., FibreCat TM -1001) and selected Johnson Matthey Pd/C catalysts has achieved nearly quantitative conversion of activated and unactivated aryl bromides in Suzuki coupling using an ethanol−water solvent system. For more challenging substrates such as p -chloroacetophenone and 3-bromothiophene, coupling could be possible by tuning the FibreCat catalysts with t -Bu 3 P. These tuned catalysts (TunaCat) are air-stable.