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January 13, 2004CirculationOpen Access

Effects of Adrenomedullin Inhalation on Hemodynamics and Exercise Capacity in Patients With Idiopathic Pulmonary Arterial Hypertension

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Why the study?

Does inhalation of aerosolized adrenomedullin improve pulmonary hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension?

Population

11 patients with idiopathic pulmonary arterial hypertension

Comparison

Inhalation of aerosolized adrenomedullin vs Placebo inhalation

Design

Other

Follow-up

immediately after inhalation

Authors

NNNoritoshi NagayaNational Cerebral and Cardiovascular CenterSKShingo KyotaniNational Cerebral and Cardiovascular CenterMUMasaaki UematsuKurume University

Discussion

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Implication

Hypothesis-generating for inhaled adrenomedullin in IPAH; prospective randomized trials needed before clinical adoption.

Structured PICO

Does inhalation of aerosolized adrenomedullin improve pulmonary hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension?

P
Population
11 patients with idiopathic pulmonary arterial hypertension
I
Intervention
Inhalation of aerosolized adrenomedullin (10 microg/kg body wt)
C
Comparator
Placebo inhalation
O
Outcome
Acute hemodynamic responses (mean pulmonary arterial pressure, pulmonary vascular resistance) and exercise capacity (peak oxygen consumption, Deltao2/DeltaW ratio) immediately after inhalationsurrogate

Inhalation of aerosolized adrenomedullin acutely improves pulmonary hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension without altering systemic hemodynamics.

Cite This Study

Nagaya et al. (2004) studied this question.

synapsesocial.com/papers/6a77c5d0e29fd788c9f78efchttps://doi.org/10.1161/01.cir.0000109493.05849.14
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Repeated inhalation of adrenomedullin ameliorates pulmonary hypertension and survival in monocrotaline rats2003 · 52 citations
  2. 2Hemodynamic, Renal, and Hormonal Effects of Adrenomedullin Infusion in Patients With Congestive Heart Failure2000 · 263 citations
  3. 3Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism2000 · 155 citations
  4. 4Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertension1999 · 210 citations
  5. 5Pulmonary vasodilation to adrenomedullin: a novel peptide in humans1995 · 83 citations