Why the study?
Does prior antithrombotic use decrease systemic blood viscosity in patients with acute ischemic stroke?
Does prior antithrombotic use decrease systemic blood viscosity in patients with acute ischemic stroke?
Prior antithrombotic use is associated with decreased systemic blood viscosity in the acute phase of ischemic stroke, potentially due to inhibition of platelet aggregation and enhanced erythrocyte deformability.
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Prior antithrombotics may alter acute hemorheology in stroke; leaves open prognostic impact and need for targeted trials.
We previously reported that middle cerebral artery (MCA) pulsatility is highly associated with systemic blood viscosity (BV) in acute ischemic stroke within 24 hours of symptom onset. We also showed that prior antithrombotic use was significantly associated with decreased BV in acute ischemic stroke patients. This study demonstrated that prior antithrombotic medication changes the hemorheological profile in the acute phase of ischemic stroke. When using antithrombotics, inhibition of platelet aggregation and enhancement of erythrocyte deformability may be associated with decreased BV.
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Kim et al. (2020) studied this question.
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