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In view of the reported biological activities of antibiotics Amicetin and Blasticidin S, 1‐(tetrahydro‐2‐pyranyl)cytosine, ‐uracil, ‐thymine and related compounds were synthesized. These compounds were prepared by the Hilbert‐Johnson method from 2‐chloro‐tetrahydropyran and corresponding 2,4‐dimethoxypyrimidines.
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Noell et al. (1966) studied this question.
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