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February 1, 1964The Journal of Experimental MedicineOpen Access

Incomplete Simian Papovavirus Sv40

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Population

cercopithecus monkey kidney cells infected with simian papovavirus SV40

Comparison

5-fluorouracil and 5-fluorodeoxyuridine vs untreated, infected cells

Design

Preclinical

Authors

JMJoseph L. MelnickStatens Serum InstitutSSSara E. StinebaughBaylor UniversityFRFred RappBoston University

Discussion

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Implication

No immediate clinical implications for SV40 or related viruses; leaves open whether FU selectively disrupts viral assembly in animal models.

Structured PICO

P
Population
cercopithecus monkey kidney cells infected with simian papovavirus SV40
I
Intervention
5-fluorouracil (FU) and 5-fluorodeoxyuridine (FUDR)
C
Comparator
untreated, infected cells
O
Outcome
replication of simian papovavirus SV40 and production of virus antigensurrogate

FU and FUDR suppress SV40 infectious virus production, but FU allows for abundant viral protein synthesis without viral assembly.

Cite This Study

Melnick et al. (1964) studied this question.

synapsesocial.com/papers/6a77cbc998f24dbf64bd9d12https://doi.org/10.1084/jem.119.2.313
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Also Consider

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  3. 3THE VACUOLATING VIRUS OF MONKEYS1961 · 53 citations
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