A novel and highly efficient AgOAc/TF-BiphamPhos catalytic system shows excellent reactivity, diastereo-/enantioselectivity and structural scope in asymmetric 1,3-dipolar cycloaddition of azomethine ylides, especially derived from various alpha-substituted alpha-amino acids, with N-substituted maleimides and other electron-deficient alkenes.
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Wang et al. (2009) studied this question.
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