High expression of long noncoding RNA plasmacytoma variant translocation 1 is an independent risk factor for recurrence after radiofrequency ablation in atrial fibrillation patients

Figures

• 

  FIGURE 1. The expression of lncRNA PVT1 in plasma of the AF patients. (A) The expression of lncRNA PVT1 in plasma of the AF patients was detected using RT‐qPCR; (B) the ROC curve of plasma lncRNA PVT1 on diagnosing AF. Independent t test was used for data comparisons in panel A and the ROC curve was used for data analysis in panel B. *p < 0.01. AF, atrial fibrillation; AUC, area under the curve; lncRNA, long noncoding RNA; PVT1, plasmacytoma variant translocation 1; ROC, receiver operating characteristic; RT‐qPCR, reverse transcription quantitative polymerase chain reaction

• 

  FIGURE 2. Comparison of lncRNA PVT1 expression before and after RFA in AF patients. The plasma lncRNA PVT1 expression before and after RFA in AF patients was detected using RT‐qPCR. Independent t test was used for data comparisons between two groups. *p < 0.01. AF, atrial fibrillation; lncRNA, long noncoding RNA; PVT1, plasmacytoma variant translocation 1; RFA, radiofrequency ablation; RT‐qPCR, reverse transcription quantitative polymerase chain reaction

• 

  FIGURE 3. Differences of plasma lncRNA PVT1 expression between non‐recurrence group and recurrence group in AF patients. (A) The expression of plasma PVT1 was different between non‐recurrent group and recurrent group; (B) the ROC curve of plasma PVT1 level on evaluating postoperative recurrence in AF patients; (C) cumulative incidence of postoperative recurrence in AF patients. Independent t test was used for data test in panel A, ROC curve was used for data analysis in panel B, and Kaplan–Meier was used for survival analysis in panel C. *p < 0.01. AF, atrial fibrillation; AUC, area under the curve; lncRNA, long noncoding RNA; PVT1, plasmacytoma variant translocation 1; ROC, receiver operating characteristic

• 

  FIGURE 4. Correlation between plasma PVT1 expression and fibrosis marker TGF‐β1 in the recurrent group. Pearson was applied to analyze the correlation between the expression of plasma lncRNA PVT1 and the level of TGF‐β1 in the (A) recurrent group and (B) non‐recurrent group. Pearson coefficient was adopted for data analysis in panels A and B. lncRNA, long noncoding RNA; PVT1, plasmacytoma variant translocation 1; TGF‐β1, transforming growth factor beta 1