February 1, 1997Expert Opinion on Therapeutic Patents
The renoprotective potential of endothelin receptor antagonists
Population
Pre-clinical models of acute and chronic renal dysfunction
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Pre-clinical ET antagonists and ECE inhibitors for renal dysfunction remain investigational; leaves open translation to clinical efficacy and safety.
Structured PICO
P
Population
Pre-clinical models of acute and chronic renal dysfunction
I
Intervention
Endothelin-converting enzyme (ECE) inhibitors and endothelin (ET) receptor antagonists
O
Outcome
Renal haemodynamic and/or structural damage
This review highlights the pre-clinical development and patent landscape of endothelin receptor antagonists and ECE inhibitors for potential renoprotective effects.
Cite This Study
Benigni et al. (1997) studied this question.