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Mechanistic uncertainties in picornavirus entry should not yet alter clinical practice; leaves open key questions for future research.
The picornavirus family contains a number of significant pathogens, such as poliovirus, rhinovirus (common cold) and foot-and-mouth disease virus. Despite having been the subject of extensive study for more than a century, we remain ignorant of the exact molecular mechanisms by which these viruses infect cells. In this article we review recent progress towards the understanding of this process and discuss what questions remain unanswered.
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Tuthill et al. (2007) studied this question.
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