The incidence of biomaterial-centred infections underlies the need to improve the properties of existing biomaterials. Combining the bioactive properties of calcia-silicate gel-glasses with that of the silver would prevent infections without the use of antibiotic drugs. Inclusion of silver into bioactive gel-glass foam scaffolds is explored using in vitro characterization techniques. The amount of silver released from Ag-doped S70C30 foams is well above the minimum bactericidal concentration (0.1 ppm) but below the cytotoxic concentration (1.6 ppm) for human cells. Primary human osteoblasts proliferate on the silver-doped gel-glasses.
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Saravanapavan et al. (2003) studied this question.
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