Aim: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions. Methods: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC. Results: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61–2.00; I2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42–2.01; I2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients. Conclusion: The NLR ratio is a variable correlated to prognosis in RCC patients.
No takes yet. Share an insight, caveat, or question.
Nunno et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: