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SUMMARY Rabbits given lead acetate, cadmium chloride, or mercuric chloride in their drinking water for 70 days and then inoculated with pseudorabies virus (3 doses, 7 days between doses) as antigen had significantly lower neutralizing antibody titers than did the controls. The titers were determined by the plaque assay method using serum samples prepared 7 (experimental day 78) and 24 (experimental day 95) days after the 1st viral inoculation was given.
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Loren D. Koller (1973) studied this question.
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