Why the study?
The complexity and chronicity of atherosclerosis have posed major challenges to fully defining molecular mechanisms and exploring more effective therapeutic targets.
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Design
Review summarizing ATVB articles published in 2017 and 2018
Animal and in vitro models extend mechanistic atherosclerosis tools; leaves open clinical translation.
A therosclerosis is initiated and propagated over decades with no overt clinical symptoms. The complexity and chronicity of its pathophysiological process have been a major challenge to fully define molecular mechanisms and explore more effective therapeutic targets. 1,2 This Recent Highlights series summarizes ATVB articles published in 2017 and 2018 on the traditional animal model systems and new approaches that have become powerful tools for studying pathogenesis and mechanisms of atherosclerosis.
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Wu et al. (2019) studied this question.
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