Prognostic Significance of Ki-67 Labeling Index in Urothelial Tumors of the Renal Pelvis and Ureter

No AccessJournal of UrologyClinical Urology: Original Article1 Jun 1996Prognostic Significance of Ki-67 Labeling Index in Urothelial Tumors of the Renal Pelvis and Ureter Mitsunobu Masuda, Masayuki Iki, Yasuo Takano, Tomoyuki Asakura, Sumio Noguchi, Ichiro Ikeda, Yoshinobu Kubota, and Masahiko Hosaka Mitsunobu MasudaMitsunobu Masuda , Masayuki IkiMasayuki Iki , Yasuo TakanoYasuo Takano , Tomoyuki AsakuraTomoyuki Asakura , Sumio NoguchiSumio Noguchi , Ichiro IkedaIchiro Ikeda , Yoshinobu KubotaYoshinobu Kubota , and Masahiko HosakaMasahiko Hosaka View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66036-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the prognostic significance of the Ki-67 labeling index in 70 patients with primary urothelial tumors of the renal pelvis and ureter. Materials and Methods: Immunohistochemical staining for Ki-67 in archival tumor materials was done by the streptavidin-biotin method. Results: Univariate survival analysis showed that the prognosis of patients with a high Ki-67 labeling index of 21.7 or more was significantly worse than that of patients with an intermediate labeling index of 13.3 to less than 21.7 (p less than 0.01) or a low labeling index of less than 13.3 (p less than 0.001). Multivariate survival analysis showed that staining for Ki-67 labeling index was significantly correlated with prognosis (p less than 0.01). Conclusions: Analysis of Ki-67 labeling index provides useful prognostic information about patients with primary urothelial tumors of the renal pelvis and ureter. References 1 : Clinical evaluation of urothelial tumors of the renal pelvis and ureter based on a new classification system. Cancer1987; 59: 1369. Google Scholar 2 : Tumor grade and stage as prognostic variables in upper tract urothelial tumors. 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Google Scholar From the Department of Urology, Yokohama City University School of Medicine, Yokohama, Department of Environmental Health, Fukui Medical School, Fukui, and Department of Pathology, Kitasato University School of Medicine, Kitasato, Japan.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKrabbe L, Bagrodia A, Haddad A, Kapur P, Khalil D, Hynan L, Wood C, Karam J, Weizer A, Raman J, Remzi M, Rioux-Leclercq N, Haitel A, Roscigno M, Bolenz C, Bensalah K, Sagalowsky A, Shariat S, Lotan Y and Margulis V (2014) Multi-institutional Validation of the Predictive Value of Ki-67 in Patients with High Grade Urothelial Carcinoma of the Upper Urinary TractJournal of Urology, VOL. 193, NO. 5, (1486-1493), Online publication date: 1-May-2015.Krabbe L, Bagrodia A, Lotan Y, Gayed B, Darwish O, Youssef R, John G, Harrow B, Jacobs C, Gaitonde M, Sagalowsky A, Shariat S, Kapur P and Margulis V (2013) Prospective Analysis of Ki-67 as an Independent Predictor of Oncologic Outcomes in Patients with High Grade Upper Tract Urothelial CarcinomaJournal of Urology, VOL. 191, NO. 1, (28-34), Online publication date: 1-Jan-2014.MASUDA M, TAKANO Y, IKI M, MAKIYAMA K, NOGUCHI S and HOSAKA M (2018) EXPRESSION AND PROGNOSTIC VALUE OF CD44 ISOFORMS IN TRANSITIONAL CELL CARCINOMA OF RENAL PELVIS AND URETERJournal of Urology, VOL. 161, NO. 3, (805-809), Online publication date: 1-Mar-1999.Masuda M, Takano Y, Iki M, Asakura T, Hashiba T, Noguchi S and Hosaka M (2018) Apoptosis in Transitional Cell Carcinoma of the Renal Pelvis and Ureter: Association With Proliferative Activity, bcl-2 Expression and PrognosisJournal of Urology, VOL. 158, NO. 3, (750-753), Online publication date: 1-Sep-1997. Volume 155Issue 6June 1996Page: 1877-1881 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.Metrics Author Information Mitsunobu Masuda More articles by this author Masayuki Iki More articles by this author Yasuo Takano More articles by this author Tomoyuki Asakura More articles by this author Sumio Noguchi More articles by this author Ichiro Ikeda More articles by this author Yoshinobu Kubota More articles by this author Masahiko Hosaka More articles by this author Expand All Advertisement PDF downloadLoading ...