Why the study?
Are tissue concentrations of lidocaine and MEGX higher in lidocaine-associated deaths compared to other patients treated with lidocaine?
Are tissue concentrations of lidocaine and MEGX higher in lidocaine-associated deaths compared to other patients treated with lidocaine?
Tissue concentrations of lidocaine greater than 15 mg/kg are associated with lidocaine-related deaths.
May inform forensic attribution of lidocaine toxicity; leaves open whether thresholds predict risk in therapeutic use.
Concentrations of lidocaine and MEGX were determined in a variety of tissues and other samples collected at autopsy. In 13 of the cases examined in which lidocaine was associated with death, tissue concentrations were greater than 15 mg/kg. Tissue concentrations in other patients treated with lidocaine were significantly lower.
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Peat et al. (1985) studied this question.
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