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Metalloporphyrin heme oxygenase inhibitors show preclinical protective effects in intracerebral hemorrhage models.
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The hemorrhagic strokes, intracerebral (ICH) and subarachnoid hemorrhage (SAH), often have poor outcomes. Indeed, the most common hemorrhagic stroke, ICH, has the highest mortality and morbidity rates of any stroke subtype. In this report, we discuss the evidence for the staging of red blood cell removal after ICH and the significance of control of this process. The protective effects of clinically relevant metalloporphyrin heme oxygenase inhibitors in experimental models of ICH and in superficial siderosis are also discussed. We also examine literature paradoxes related to both heme and heme oxygenase in various disorders of the central nervous system. Last, new data are presented that support the concept that heme, although primarily a pro-oxidant, can also have antioxidant properties.
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Wagner et al. (2004) conducted a review in Hemorrhagic stroke (intracerebral hemorrhage and subarachnoid hemorrhage) and superficial siderosis. Metalloporphyrin heme oxygenase inhibitors and red blood cell removal was evaluated. Metalloporphyrin heme oxygenase inhibitors show protective effects in experimental models of intracerebral hemorrhage, and heme exhibits both pro-oxidant and antioxidant properties.
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