January 14, 2006AJP Heart and Circulatory PhysiologyOpen Access

Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle

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Population

Dystrophin-deficient mdx mouse hearts (left atria, ventricular homogenates, and isolated ventricular myocytes)

Design

Preclinical

Authors

PWPeter WoolfUnited States Food and Drug Administration LLLucy LuCured Foundation RCRenée A. Cornford-Nairn

Discussion

Member takes

Implication

Hypothesis-generating for DHPR dysfunction in dystrophic cardiomyopathy; leaves open relevance to human DMD and therapeutic targeting.

Structured PICO

Population

Dystrophin-deficient mdx mouse hearts (left atria, ventricular homogenates, and isolated ventricular myocytes)

Intervention

Dihydropyridine agonist BAY K 8644 and antagonist nifedipine

Outcome

Dihydropyridine receptor affinity, protein/mRNA levels, and L-type calcium channel propertiessurrogate

Dystrophin deficiency in mdx mice alters dihydropyridine receptors and delays L-type calcium channel inactivation, potentially contributing to calcium overload in dystrophic cardiac muscle.

Cite This Study

Woolf et al. (2006) studied this question.

synapsesocial.com/papers/6a7809a598f24dbf64bdb265 https://doi.org/10.1152/ajpheart.00844.2005

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Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider