Answers are grounded in this paper and cite their sources.
In vitro study reveals pH-dependent bactericidal uptake and macromolecular inhibition by glutaraldehyde in Escherichia coli, highlighting its mechanism of irreversible cellular cross-linking.
S ummary . Glutaraldehyde was readily taken up by Escherichia coli cells with an increase in solutions buffered to pH 7·9; it was paralleled by a corresponding increase in bactericidal activity. Attempts to desorb glutaraldehyde from the cells indicated that the drug molecules were firmly bound. Inhibition of synthesis of macromolecules was demonstrated. Cell walls of E. coli exhibited a much reduced rate of hydrolysis following treatment with glutaraldehyde.
No takes yet. Share an insight, caveat, or question.
McGucken et al. (1973) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: