Key result
Inflammatory bowel disease increases cardiovascular risk through immune dysregulation, gut dysbiosis, and endothelial dysfunction.
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Cardiovascular diseases (CVD) are the leading cause of mortality worldwide despite an aggressive reduction of traditional cardiovascular risk factors. Underlying inflammatory conditions such as inflammatory bowel disease (IBD) increase the risk of developing CVD. A broad understanding of the underlying pathophysiological processes between IBD and CVD is required to treat and prevent cardiovascular events in patients with IBD. This review highlights the commonality between IBD and CVD, including dysregulated immune response, genetics, environmental risk factors, altered gut microbiome, stress, endothelial dysfunction and abnormalities, to shed light on an essential area of modern medicine.
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Kumarapperuma et al. (2023) conducted a review in Inflammatory bowel disease and cardiovascular disease. Inflammatory bowel disease was evaluated on Cardiovascular disease mechanisms. Inflammatory bowel disease increases cardiovascular disease risk via shared mechanisms including immune dysregulation, altered gut microbiome, genetics, and endothelial dysfunction.
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