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August 9, 2026ImmunoOpen Access

Transcriptomic Analysis Identifies Putative Hematopoietic Co-Expression Networks in Icariin-Mediated Recovery from Cyclophosphamide-Induced Immunosuppression

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Authors

NLNan LiSJShaochen JiangZDZhe Ding

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Overview

Randomized trial identifies immune recovery pathways in mice treated with icariin post cyclophosphamide exposure, suggesting new therapeutic targets.

Key Points

  • This research aims to explore the impact of icariin on recovery from cyclophosphamide-induced immunosuppression using transcriptomic analysis.
  • Male mice underwent treatment with control, cyclophosphamide, and cyclophosphamide plus icariin (20, 40, or 80 mg/kg).
  • Integrated phenotype measurements with RNA sequencing and analyzed data using differential expression and WGCNA methods.
  • Used permutational multivariate analysis of variance to assess transcriptomic data.
  • Icariin treatment showed significant improvements in spleen index and body weight at 80 mg/kg (PERMANOVA, F = 17.18, R2 = 0.873, p < 0.001).
  • Weighted gene co-expression network analysis revealed recovery-related turquoise and royalblue modules associated with Myb and Gata1, respectively.
  • Dose-dependent confirmation of immune transcripts was achieved via RT-qPCR, indicating uneven recovery patterns.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a782d3b2e1896536c840164https://doi.org/10.3390/immuno6030053
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