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August 9, 2026Environmental Science & Technology

ANovel Framework of an Adverse Outcome Pathway Targetingthe Eye Lens: Mechanistic Insights from 4,5-Dichloro-2- n -octyl-4-isothiazolin-3-one (DCOIT) Exposure inCataract Etiology

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Authors

JLJing LiMAMaaz AhmadCHChenyan Hu

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Overview

Randomized trial investigates pollutant exposure effects on lens function in marine medaka, highlighting ecological risks.

Key Points

  • This study aims to explore the molecular mechanisms by which DCOIT exposure affects eye lens function and structure.
  • Integrated ex vivo, in silico, in vitro, and in vivo approaches were employed to investigate the contaminant's effects.
  • Pull-down screening identified lens crystallin proteins as molecular targets interacting with DCOIT.
  • Gene expression profiling and proteomic analyses assessed the impact on lens protein homeostasis.
  • Exposure to DCOIT led to progressive lens opacity and impaired optomotor responses in marine medaka.
  • Crystallin aggregation was confirmed, indicating reduced lens transparency and disrupted protein stability.
  • Concentration-dependent upregulation of crystallin and photoreceptor genes highlighted adaptive lens responses.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a782d3b2e1896536c840249https://doi.org/10.1021/acs.est.6c00969
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