Why the study?
Rapid-response RNA vaccine manufacturing against viral epidemics requires quality-oriented, disease-agnostic manufacturing protocols established ahead of outbreaks.
Application of a Quality by Design framework to RNA vaccine manufacturing provides a design space for bioreactors to optimize cost-yield and automate rapid-response production.
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Introduces first QbD framework for RNA vaccine manufacturing; leaves open validation for scalable pandemic response.
Berg et al. (2021) studied this question.
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