Efficacy and safety of a combination of monoclonal antibodies and chemoradiotherapy for the treatment of locally advanced cervical cancer in Chinese patients: a systematic review and meta-analysis

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This study aims to assess the efficacy and safety of monoclonal antibodies combined with chemoradiotherapy for treating locally advanced cervical cancer in Chinese patients.
Systematic search in multiple databases for randomized controlled trials and studies on monoclonal antibodies for LACC.
Data extraction and bias assessment conducted independently by two researchers.
Meta-analysis performed using Stata version 14.0 software.
Pooled objective response rate was 90% (95% CI: 0.85-0.95).
1-, 2-, 3-, and 5-year overall survival rates were 98%, 93%, 89%, and 80%, respectively.
Common adverse events included gastrointestinal reactions (55%) and leukopenia (51%).

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Systematic review evaluates efficacy and safety of monoclonal antibodies with chemoradiotherapy for cervical cancer, suggesting promising outcomes.

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Feng et al. (2026) studied this question.

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