Key result
High-volume training significantly increased circulating miR-126 (2.8-fold at 60 min post-exercise) and miR-16 compared to high-intensity interval training in young male cyclists.
Why the study?
Does high-intensity interval training compared to high-volume training alter circulating vascular regulating microRNAs in healthy young male cyclists?
RCT (n=12)
Randomly chosen order (crossover)
No
Does high-intensity interval training compared to high-volume training alter circulating vascular regulating microRNAs in healthy young male cyclists?
Effect estimate: 2.8-fold increase
p-value: p=0.003
Acute high-volume endurance exercise, but not high-intensity interval training, upregulates circulating vascular regulating microRNAs (miR-16, miR-126) in healthy children.
Should not alter training prescriptions; leaves open miR-126 as volume-sensitive biomarker in athletes.
AIM: The aim of the present study was to analyze the response of vascular circulating microRNAs (miRNAs; miR-16, miR-21, miR-126) and the VEGF mRNA following an acute bout of HIIT and HVT in children. METHODS: Twelve healthy competitive young male cyclists (14.4 ± 0.8 years; 57.9 ± 9.4 ml·min(-1)·kg(-1) peak oxygen uptake) performed one session of high intensity 4 × 4 min intervals (HIIT) at 90-95% peak power output (PPO), each interval separated by 3 min of active recovery, and one high volume session (HVT) consisting of a constant load exercise for 90 min at 60% PPO. Capillary blood from the earlobe was collected under resting conditions, during exercise (d1 = 20 min, d2 = 30 min, d3 = 60 min), and 0, 30, 60, 180 min after the exercise to determine miR-16, -21, -126, and VEGF mRNA. RESULTS: HVT significantly increased miR-16 and miR-126 during and after the exercise compared to pre-values, whereas HIIT showed no significant influence on the miRNAs compared to pre-values. VEGF mRNA significantly increased during and after HIIT (d1, 30', 60', 180') and HVT (d3, 0', 60'). CONCLUSION: RESULTS of the present investigation suggest a volume dependent exercise regulation of vascular regulating miRNAs (miR-16, miR-21, miR-126) in children. In line with previous data, our data show that acute exercise can alter circulating miRNAs profiles that might be used as novel biomarkers to monitor acute and chronic changes due to exercise in various tissues.
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Kilian et al. (2016) conducted an RCT in Healthy competitive young male cyclists (n=12). High-volume training (HVT) vs High-intensity interval training (HIIT) vs. Baseline and between-protocol comparison was evaluated on Circulating miR-126 levels at 60 minutes post-exercise (2.8-fold increase, p=0.003). High-volume training significantly increased circulating miR-126 (2.8-fold at 60 min post-exercise) and miR-16 compared to high-intensity interval training in young male cyclists.
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