The effect of curcumin on ethanol induced liver toxicity was evaluated. The increased levels of aspartate transaminase and alkaline phosphatase induced by ethanol were significantly lowered by curcumin. Elevated serum cholesterol, phospholipids and free fatty acids were observed in ethanol fed rats, but on curcumin treatment they decreased. We have also observed a marked decrease in the levels of thiobarbituric acid reactive substances in serum of alcoholic rats fed curcumin. Thus this study shows that curcumin offers protection against ethanol induced toxicity.
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Rajakrishnan et al. (1998) studied this question.
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