Key result
Higher scores of Yang-Xu and Stasis on the Body Constitution Questionnaire, combined with age, BMI, and hypertension, predicted coronary artery disease with an AUC of 0.896.
Why the study?
Identifying patients with high risk of CAD is often difficult in outpatient clinics, motivating exploration of whether body constitution measurements can predict CAD diagnosis risk.
Does the Body Constitution Questionnaire predict the risk of coronary artery disease in patients with chest pain?
Observational (n=619)
Does the Body Constitution Questionnaire predict the risk of coronary artery disease in patients with chest pain?
The Body Constitution Questionnaire, specifically Yang-Xu and Stasis scores, combined with clinical variables, shows potential as a first-line diagnostic tool for predicting CAD risk in patients with chest pain.
May support body constitution tools for CAD risk stratification in chest pain; hypothesis-generating and requires prospective validation before practice change.
Background . Identifying patients with high risk of coronary artery disease (CAD) is often difficult in outpatient clinic settings. This study aimed to explore if the measurement of body constitution can be adopted to predict the risk of CAD diagnosis. The objective of this study is to conduct a prospective observational study and a case-control study to answer the research question. Study Design. Part 1 (prospective observational study): a total of 143 patients with chest pain and admitted to receive cardiac catheterization were enrolled, and 108 of them were diagnosed with CAD. Part 2 (case-control study): the above 108 CAD patients and 476 healthy controls matched by age and gender from the participants of Taiwan Biobank were adopted for comparison. Main Outcome Measures . The body constitution of both patients and healthy controls were measured by the Body Constitution Questionnaire (BCQ). Each one received scores of Yang-Xu ( Yang-deficiency ), Yin-Xu ( Yin-deficiency ), and Stasis . These 3 scores together with demographic characteristics and CAD risk factors were used in the logistic multiple regression model to predict the risk of CAD. Results . (Part 1) No difference was found between the scores of Yang-Xu , Yin-Xu , and Stasis between the patients with and without CAD. (Part 2) The scores of Yang-Xu , Yin-Xu , and Stasis of the CAD patients were significant higher those of the healthy controls. Yang-Xu and Stasis scores were obtained with age, BMI, and hypertension in the model with prediction rate 89.0%. The area under receiver operating characteristic curve of this model was 0.896. Conclusions . This study is the first to apply Chinese body constitution concepts and measurable variables to assess the risk of having CAD of the patients with chest pain prior to receiving cardiac catheterization. The higher scores of Yang-Xu and Stasis were found to be risk factors. Our results revealed that BCQ has the potential to be a first-line diagnostic tool for patients with chest pain to facilitate early recognition and diagnosis of CAD.
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Huang et al. (2019) conducted an observational in Coronary Artery Disease (n=619). Body Constitution Questionnaire (BCQ) scores (Yang-Xu, Yin-Xu, Stasis) vs. Healthy controls and patients without CAD was evaluated on Risk of CAD diagnosis. Higher scores of Yang-Xu and Stasis on the Body Constitution Questionnaire, combined with age, BMI, and hypertension, predicted coronary artery disease with an AUC of 0.896.
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