Key result
Rigid body rotation occurred in 53.3% of patients with LVNC and was associated with worse NYHA functional status (P<0.0001) but not with more adverse remodeling compared to normal LV rotation.
Why the study?
Is abnormal left ventricular twist associated with more adverse LV remodelling in patients with left ventricular noncompaction?
Observational (n=119)
Is abnormal left ventricular twist associated with more adverse LV remodelling in patients with left ventricular noncompaction?
p-value: p=<0.0001
In patients with left ventricular noncompaction, rigid body rotation is common and associated with worse functional status, but it does not indicate more adverse echocardiographic remodelling compared to normal LV rotation.
Questions rigid body rotation as remodeling marker in LVNC; leaves open its prognostic value and management role.
AIMS: Left ventricular (LV) twist is an important component of systolic function. The effect of abnormal LV twist on adverse remodelling of the heart in left ventricular noncompaction (LVNC) is unknown. This study used speckle-tracking echocardiography to evaluate LV twist in patients with LVNC and determine whether abnormal LV twist is associated with more adverse LV remodelling. METHODS AND RESULTS: Clinical, echocardiographic, and myocardial deformation characteristics were prospectively compared between 60 subjects diagnosed with LVNC and 59 age-matched healthy controls. Net instantaneous twist was defined as: peak apical rotation minus isochronous basal rotation. Normal rotation during systole was defined based on the 2010 ASE/EAE consensus document. Rigid body rotation (RBR) was determined present if the apex and base moved in the same direction during ejection. Rigid body rotation was found in 32 (53.3%) subjects with LVNC. The 28 subjects with LVNC and normal LV rotation had diminished apical rotation, basal rotation, and net twist compared with normal controls (P < 0.0001). Patients with LVNC and RBR had worse NYHA functional status (P < 0.0001), but similar echocardiographic indices of remodelling, ejection fraction, and strain parameters as those with LVNC and normal LV rotation. CONCLUSION: Left ventricular twist is diminished in subjects with LVNC and normal LV rotation. Rigid body rotation occurs in 53.3% of subjects with LVNC and is not associated with more adverse remodelling than subjects with LVNC and normal LV rotation.
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Peters et al. (2013) conducted an observational in Left ventricular noncompaction (n=119). Left ventricular noncompaction vs. Age-matched healthy controls was evaluated on Left ventricular twist and echocardiographic indices of remodelling (p=<0.0001). Rigid body rotation occurred in 53.3% of patients with LVNC and was associated with worse NYHA functional status (P<0.0001) but not with more adverse remodeling compared to normal LV rotation.
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