Late-Onset Adverse Reactions Related to Hyaluronic Acid Dermal Filler for Aesthetic Soft Tissue Augmentation

Hyaluronic acid (HA) fillers have been the choice material for soft tissue augmentation in the last decade. Although they are considered safe, there could be adverse reactions in the subsequent months or years to the treatment. However, these reactions have hardly ever been reported in the literature. This article considers 2 cases of delayed adverse reactions related to HA dermal filler for soft tissue augmentation with oral manifestation. It should be, before all, emphasized that HA filler is a safe and well-recognized treatment for soft tissue augmentation, despite the fact that delayed adverse effects may later occur after treatment, and clinicians should be aware of it when establishing a definitive oral diagnosis.