Presenting pulse pressure predicts thrombolytic therapy-related intracranial hemorrhage. Thrombolytic Predictive Instrument (TPI) Project results.

194 subjects (19 with treatment-related intracranial hemorrhages confirmed by computed tomography and 175 matched controls) drawn from a cohort of 3,483 Thrombolytic Predictive Instrument (TPI) Project subjects receiving thrombolytic therapy for acute myocardial infarction.

Presenting pulse blood pressure and excess pulse pressure (extent to which pulse pressure exceeded 40 mm Hg for systolic blood pressures ≥120 mm Hg)

Systolic, diastolic, and mean arterial blood pressures

Thrombolysis-related intracranial hemorrhage confirmed by computed tomographysafety