Key result
Balloon denudation rapidly induces transient c-fos and c-myc proto-oncogene expression after arterial injury.
Answers are grounded in this paper and cite their sources.
In order to study the earliest phenomenons occurring in the arterial wall after balloon angioplasty, the level of expression of the proto-oncogenes, c-fos and c-myc, was studied in rabbit aorta after balloon denudation by using Northern blot analysis. Both c-fos and c-myc are rapidly and transitorily induced (maximal at 30 min and 2 h after mechanical injury for c-fos and c-myc respectively). By comparison, infusion of norepinephrine increases oncogene expression in normal non-denuded rabbit aorta after 1 h, but the combination of both mechanical and hormonal stimuli do not lead to a more important induction than balloon denudation alone.
No takes yet. Share an insight, caveat, or question.
Bauters et al. (1992) studied Arterial wall injury / restenosis after balloon angioplasty. Balloon denudation and/or norepinephrine infusion vs. Normal non-denuded rabbit aorta was evaluated on Level of expression of proto-oncogenes c-fos and c-myc via Northern blot analysis. Balloon denudation in rabbit aorta rapidly and transitorily induced c-fos and c-myc proto-oncogene expression, peaking at 30 minutes and 2 hours after injury, respectively.
Synapse has enriched 10 related papers. Consider them for comparative context: