September 25, 2002Artificial Organs
Mock Loop Testing of On‐X Prosthetic Mitral Valve with Doppler Echocardiography
Key result
In vitro testing of On-X prosthetic mitral valves demonstrated an effective orifice area of 2.1 cm2, a performance index of 0.56 at 3.5 L/min cardiac output, and regurgitant volumes below 6 ml.
Population
In vitro computer-controlled mock loop system testing two samples of the On-X Mitral 27/29 and one sample of…
Design
Preclinical
Authors
Discussion
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Implication
In vitro hydrodynamics alone do not guide valve selection; leaves open in vivo validation before clinical consideration.
Structured PICO
P
Population
In vitro testing of three On-X prosthetic mitral valve samples (two Mitral 27/29, one Conform-X Mitral 25/33) using a computer-controlled mock loop system.
I
Intervention
Hemodynamic testing under three pressure conditions (ventricular systolic pressure of 100, 130, and 160 mm Hg) at three different heart rates (60, 100, and 140 beats/min) and simulated fibrillation.
O
Outcome
Transvalvular pressure gradient, flow, and transthoracic Doppler echocardiography parameters (effective orifice area, performance index, regurgitant volume).surrogate
In vitro mock loop testing demonstrates that On-X prosthetic mitral valves have excellent hydrodynamic characteristics, including an effective orifice area of 2.1 cm2 and low regurgitant volumes.
Cite This Study
Verdonck et al. (2002) studied Prosthetic mitral valve testing (n=3). On-X prosthetic mitral valve was evaluated on Hydrodynamic characteristics (effective orifice area, performance index, regurgitant volume). In vitro testing of On-X prosthetic mitral valves demonstrated an effective orifice area of 2.1 cm2, a performance index of 0.56 at 3.5 L/min cardiac output, and regurgitant volumes below 6 ml.