Misregulation of gene expression often leads to severe defects in the development of an organism or to uncontrolled cell growth. Artificial transcription factors can control the expression of the genes concerned to restore normal cell regulation. Dervan and co-workers have synthesized several DNA-binding polyamides (see picture: TALE (yellow) is a class of homeobox protein) that show potential for the treatment of diseases such as cancer.
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Schmitz et al. (2004) studied this question.
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