Key result
Three months of monotherapy with diuretics, calcium antagonists, or ACE inhibitors in 98 hypertensive patients impaired zinc status by decreasing serum and/or erythrocyte zinc concentrations.
RCT (n=98)
Randomized
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BACKGROUND: Antihypertensive drugs affect mineral metabolism, inflammation, and the oxidative state. The aim of this study was to evaluate the effects of antihypertensive monopharmacotherapy with diuretics, β-blockers, calcium antagonists (Ca-antagonists), angiotensin-converting enzyme inhibitors (ACE-I), and angiotensin II receptor antagonists (ARBs) on zinc (Zn), iron (Fe), and copper (Cu) status, parameters of oxidative and inflammatory states, and glucose and lipid metabolism in patients with newly diagnosed primary arterial hypertension (AH). METHODS: Ninety-eight hypertensive subjects received diuretics, β-blockers, Ca-antagonists, ACE-I, or ARB for three months. Zn, Fe, and Cu concentrations were determined in blood, urine, and hair. RESULTS: A decrease in zinc serum and erythrocyte concentration and an increase in zinc urine concentration were registered after diuretic administration. Ca-antagonists led to a decrease in erythrocyte zinc concentration. A decrease in serum zinc concentration was observed after ACE-I. A decrease in triglyceride serum concentration was noted after ACE-I therapy, and a decrease in tumor necrosis factor-α serum concentration was seen following administration of Ca-antagonists. Hypotensive drugs led to decreases in catalase and superoxide dismutase serum concentrations. CONCLUSIONS: Three-months of monotherapy with diuretics, Ca-antagonists, or ACE-I impairs zinc status in patients with newly diagnosed primary AH. Antihypertensive monopharmacotherapy and zinc metabolism alterations affect lipid metabolism, the oxidative state, and the inflammatory state.
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Suliburska et al. (2018) conducted an RCT in Newly diagnosed primary arterial hypertension (n=98). Antihypertensive monotherapy (diuretics, beta-blockers, calcium antagonists, ACE inhibitors, or ARBs) vs. Active comparator arms among the five antihypertensive drug classes was evaluated on Zinc, iron, and copper concentrations in blood, urine, and hair, as well as oxidative, inflammatory, glucose, and lipid metabolism parameters. Three months of monotherapy with diuretics, calcium antagonists, or ACE inhibitors in 98 hypertensive patients impaired zinc status by decreasing serum and/or erythrocyte zinc concentrations.
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