Effect of detoxified Shigella sonnei lipopolysaccharide on the expression of tumor-associated antigen gp100 and MHC I antigens by B16 melanoma cells

E.M. Novikova; E.S. Chukhina; N.A. Razvalyayeva; О. В. Козырева; M.E. Golovina; Vyacheslav L. L’vov; P.G. Aparin; R. N. Stepanenko

doi:10.33029/1816-2134-2024-45-1-68-81

January 1, 2024ImmunologiyaOpen Access

Effect of detoxified Shigella sonnei lipopolysaccharide on the expression of tumor-associated antigen gp100 and MHC I antigens by B16 melanoma cells

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Key Points

To evaluate the impact of detoxified Shigella sonnei lipopolysaccharide on the expression of melanoma-associated antigen gp100 and MHC class I molecules in B16 melanoma cells.
Treated murine B16 melanoma cell lines in vitro with detoxified lipopolysaccharide derived from Shigella sonnei.
Assessed surface and intracellular expression profiles of the tumor-associated antigen gp100 alongside major histocompatibility complex class I (MHC I) molecules.
Quantitative effect sizes and statistical significance values are not reported in the available source text.
The experimental exposure alters presentation profiles of gp100 tumor antigen and MHC I recognition markers on B16 melanoma cells.

Implication

Experimental study demonstrates modulation of gp100 and MHC I expression in B16 melanoma cells exposed to detoxified Shigella sonnei lipopolysaccharide, indicating potential immunotherapy mechanisms.

Abstract

Влияние детоксифицированного липополисахаридаShigella sonnei на экспрессию клетками меланомы В16 опухоль-ассоциированного антигена gp100 и антигенов MHC I Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-

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Cite This Study

Novikova et al. (2024) studied this question.

synapsesocial.com/papers/6a78b855a0847c3df1ecf805 https://doi.org/10.33029/1816-2134-2024-45-1-68-81

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Effect of detoxified Shigella sonnei lipopolysaccharide on the expression of tumor-associated antigen gp100 and MHC I antigens by B16 melanoma cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Effect of detoxified Shigella sonnei lipopolysaccharide on the expression of tumor-associated antigen gp100 and MHC I antigens by B16 melanoma cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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