Answers are grounded in this paper and cite their sources.
n-Butyllithium/N,N,N',N'-tetramethylethylenediamine-mediated ortholithiations of aryloxazolines are described. Methyl substituents on the aryloxazoline and substituents at the meta position of the arenes (methoxy, oxazolinyl, and fluoro) influence the rates and the mechanisms. Monomer- and dimer-based reactions are implicated. Density functional calculations probe details of the mechanism and suggest the origins of cooperative effects in meta-substituted aryl oxazolines.
No takes yet. Share an insight, caveat, or question.
Chadwick et al. (2007) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: