A Case of Metastatic Malignant Melanoma Whose Primary Lesion Had Completely Regressed with Melanoma-associated Vitiligo

Shogo Hara; Yoshiaki Kubo; Yuichi Senzaki; Daisuke Fukumoto; Kazutoshi Murao; Yuki Miyaoka; Hirotsugu Takiwaki; Seiji Arase; Yasuhiko Nishioka

doi:10.2336/nishinihonhifu.67.482

January 1, 2005The Nishinihon Journal of DermatologyOpen Access

A Case of Metastatic Malignant Melanoma Whose Primary Lesion Had Completely Regressed with Melanoma-associated Vitiligo

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Key Points

To describe a rare case of metastatic malignant melanoma presenting with generalized vitiligo and complete spontaneous histological regression of the primary cutaneous tumor.
Evaluated a 72-year-old female presenting with axillary lymph node metastasis and an irregular halo-surrounded forearm macule using histopathology, S-100, and HMB-45 immunohistochemistry.
Administered multimodal therapy consisting of dacarbazine chemotherapy, local interferon-beta injections, lymph node dissection, and subsequent tumor antigen peptide-pulsed dendritic cell immunotherapy.
Histopathology of the suspected primary forearm lesion demonstrated complete tumor regression, characterized by dense dermal melanophages and loss of basal melanin without residual tumor cells.
Immunotherapy and chemotherapy failed to halt disease progression, with emergence of new distant metastases culminating in fatal respiratory failure approximately 1.5 years after presentation.

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Implication

Case report describes fatal metastatic melanoma following complete spontaneous primary lesion regression in an older woman, highlighting immune-mediated vitiligo alongside aggressive progression.

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Hara et al. (2005) studied this question.

synapsesocial.com/papers/6a78be856789de8d0af7ec91 https://doi.org/10.2336/nishinihonhifu.67.482

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A Case of Metastatic Malignant Melanoma Whose Primary Lesion Had Completely Regressed with Melanoma-associated Vitiligo

Key Points

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Implication

Discussion

Cite This Study

A Case of Metastatic Malignant Melanoma Whose Primary Lesion Had Completely Regressed with Melanoma-associated Vitiligo

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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