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March 17, 2018Acta Biochimica PolonicaOpen Access

Simvastatin treatment in patients undergoing open AAA repair decreased Cav-1 (p<0.05) and increased eNOS expression (p<0.01) in the aneurysmal wall compared to non-statin controls.

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Why the study?

Does simvastatin modulate Cav-1 and eNOS expression in patients undergoing open abdominal aortic aneurysm repair?

Population

36 patients who underwent open abdominal aortic aneurysm (AAA) repair

Comparison

Simvastatin treatment vs Non-statin treatment

Design

Case-control

Key result

Simvastatin treatment in patients undergoing open AAA repair decreased Cav-1 (p<0.05) and increased eNOS expression (p<0.01) in the aneurysmal wall compared to non-statin controls.

Authors

KKKarolina KowalskaDHDominika Ewa Habrowska‐GórczyńskaCNChristoph Neumayer

Discussion

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Overview

Simvastatin-associated Cav-1/eNOS shifts in AAA tissue are hypothesis-generating; prospective studies needed before any clinical consideration.

Key Points

  • To determine whether simvastatin modulates Caveolin-1 and endothelial nitric oxide synthase expression, and to examine its association with cytokine and Toll-like receptor 4 levels in abdominal aortic aneurysm tissue.
  • Conducted a 1:2 case-control study in patients undergoing open abdominal aortic aneurysm repair.
  • Compared non-statin-treated patients (n=12) to simvastatin-treated patients (n=24) to evaluate tissue expression of Cav-1, eNOS, TLR4, and inflammatory cytokines.
  • Simvastatin treatment significantly decreased Cav-1 expression (p<0.05) and increased eNOS expression (p<0.01) in the aneurysm wall in a potentially dose-dependent manner.
  • Treatment was associated with a trend toward decreased pro-inflammatory IL-6 and IL-17 levels (p>0.05) and increased anti-inflammatory IL-10 levels (p=0.055), whereas TLR4 expression was unchanged.

Study Design

Type

Case-Control (n=36)

Structured PICO

Does simvastatin modulate Cav-1 and eNOS expression in patients undergoing open abdominal aortic aneurysm repair?

P
Population
36 patients who underwent open abdominal aortic aneurysm repair, including 24 treated with simvastatin and 12 non-statin controls.
E
Exposure
Simvastatin treatment
C
Comparator
Non-statin treatment
O
Outcome
Cav-1 and eNOS expression in the AAA wallsurrogate

Main Result

p-value: p=<0.05 and <0.01

Simvastatin modulates Cav-1 and eNOS expression in the aneurysmal wall, suggesting a potential mechanism for statin benefit in AAA patients.

Cite This Study

Kowalska et al. (2018) conducted a case-control in abdominal aortic aneurysm (n=36). Simvastatin vs. Non-statin was evaluated on Cav-1 and eNOS expression in the AAA wall (p=<0.05 and <0.01). Simvastatin treatment in patients undergoing open AAA repair decreased Cav-1 (p<0.05) and increased eNOS expression (p<0.01) in the aneurysmal wall compared to non-statin controls.

synapsesocial.com/papers/6a78c1282e130d02afed4ba5https://doi.org/10.18388/abp.2017_2305
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