The novel heart rate variability parameter Breath Concurrence 6 (BC6) significantly predicted arrhythmic mortality (HR 0.451) and was the only parameter to significantly discriminate between arrhythmic and non-arrhythmic mortality.
Cohort (n=634)
Double-blind
Yes
Do the novel HRV parameters BC6 and PE, combined with deceleration capacity, improve the discrimination between arrhythmic and non-arrhythmic mortality risk in post-MI patients with LVEF ≤40%?
The novel heart rate variability parameters BC6 and PE, when combined with deceleration capacity, improve the discrimination between arrhythmic and non-arrhythmic mortality risk in post-MI patients with reduced ejection fraction.
Hazard Ratio: 0.451 (95% CI 0.246–0.826)
p-value: p=0.010
The effective discrimination between patients at risk of Arrhythmic Mortality (AM) and Non-Arrhythmic Mortality (NAM) constitutes one of the important unmet clinical needs. Successful risk assessment based on Electrocardiography (ECG) records is greatly improved by the combination of different indices reflecting not only the pathological substrate but also the autonomic regulation of cardiac electrophysiology. This study assesses the cardiac risk stratification capacity of two new Heart Rate Variability (HRV) parameters, Breath Concurrence 6 (BC6) -sinusoidal RR variability of 6 heart beats per breath cycle- and Primary Ectopia (PE) -presence of early ventricular contractions of any etiology- together with the Deceleration Capacity (DC). While BC6 characterizes the response to physiological and pathophysiological stimuli, PE qualifies autonomic cardiac electrophysiology. The analysis of the European Myocardial Infarct Amiodarone Trial (EMIAT) database indicates that BC6 is related with the risk of Arrhythmic Mortality (AM) and PE with the risk of Non-Arrhythmic Mortality. BC6 is the only single parameter that significantly discriminates between AM and NAM. While the combination of BC6 and DC contributes to the identification of AM risk, PE together with DC improves the prediction of NAM in patients with severe ischemic heart disease.
Gañán‐Calvo et al. (Tue,) conducted a cohort in Acute myocardial infarction (n=634). Breath Concurrence 6 (BC6) and Primary Ectopia (PE) vs. Patients with higher values of BC6 or lower values of PE was evaluated on Arrhythmic Mortality (AM) (HR 0.451, 95% CI 0.246-0.826, p=0.010). The novel heart rate variability parameter Breath Concurrence 6 (BC6) significantly predicted arrhythmic mortality (HR 0.451) and was the only parameter to significantly discriminate between arrhythmic and non-arrhythmic mortality.