March 11, 2022DiabetologiaOpen Access

High-intensity interval training for 12 weeks improves cardiovascular autonomic function but not somatosensory nerve function and structure in overweight men with type 2 diabetes

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Type 2 diabetes and overweight/obesity (n=43). Intervention: High-intensity interval training (HIIT) vs. Baseline (pre-intervention). Primary outcome: Spontaneous baroreflex sensitivity (BRS-allSeq) in type 2 diabetes group (p=<0.05).

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Key result

In overweight men with type 2 diabetes, 12 weeks of supervised high-intensity interval training improved baroreflex sensitivity, resting heart rate, and orthostatic blood pressure regulation, but did not improve somatosensory nerve function.

Why the study?

It remained unclear whether and which modality of exercise training may exert favourable effects on somatosensory and autonomic nerve tests in people with type 2 diabetes.

Does 12 weeks of supervised high-intensity interval training improve cardiovascular autonomic and somatosensory nerve function in overweight men with type 2 diabetes?

Population

20 overweight men with type 2 diabetes and 23 male glucose-tolerant controls

Comparison

Supervised high-intensity interval training intervention over 12 weeks assessed before vs after

Design

Interventional cohort study

Follow-up

12 weeks

Authors

GBGidon J. BönhofPaderborn University ASAlexander StromDeutsches Diabetes-Zentrum e.V.MAMaria ApostolopoulouUniversity of Thessaly

Discussion

Member takes

Implication

Exercise effects on nerve function in type 2 diabetes remain unclear; larger trials needed before clinical adoption.

Study Design

Type

Cohort (n=43)

Multicenter

Structured PICO

Does 12 weeks of supervised high-intensity interval training improve cardiovascular autonomic and somatosensory nerve function in overweight men with type 2 diabetes?

Population

43 overweight, sedentary men aged 30-65 years (20 with type 2 diabetes and 23 with normal glucose tolerance) underwent a 12-week supervised high-intensity interval training program.

Intervention

Supervised high-intensity interval training (HIIT) on a cycle ergometer for 35 minutes, 3 non-consecutive days per week for 12 weeks.

Comparator

Normal glucose tolerance (NGT) control group receiving the same HIIT intervention, as well as baseline vs. follow-up comparisons within groups.

Outcome

Cardiovascular autonomic and somatosensory nerve function, intraepidermal nerve fibre density (IENFD), clinical scores, nerve conduction studies, quantitative sensory testing, heart rate variability, postural change in systolic blood pressure, and spontaneous baroreflex sensitivity (BRS) at 12 weeks.surrogate

Main Result

Absolute Event Rate: 14.6% vs 8.82%

p-value: p=<0.05

In overweight men with type 2 diabetes, 12 weeks of supervised high-intensity interval training improved cardiovascular autonomic function and orthostatic blood pressure regulation, but did not alter somatosensory nerve function.

Limitations

Moderate sample size of exclusively male individuals
Most participants did not present with impaired peripheral or autonomic nerve function at baseline
Lack of a combined exercise and dietary intervention
12 weeks of HIIT may not be long enough to induce favourable effects on peripheral nerve function and/or structure

Cite This Study

Bönhof et al. (2022) conducted a cohort in Type 2 diabetes and overweight/obesity (n=43). High-intensity interval training (HIIT) vs. Baseline (pre-intervention) was evaluated on Spontaneous baroreflex sensitivity (BRS-allSeq) in type 2 diabetes group (p=<0.05). In overweight men with type 2 diabetes, 12 weeks of supervised high-intensity interval training improved baroreflex sensitivity, resting heart rate, and orthostatic blood pressure regulation, but did not improve somatosensory nerve function.

synapsesocial.com/papers/6a78dcd9c284d7a4ba5ac90b https://doi.org/10.1007/s00125-022-05674-w

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High-intensity interval training for 12 weeks improves cardiovascular autonomic function but not somatosensory nerve function and structure in overweight men with type 2 diabetes

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

High-intensity interval training for 12 weeks improves cardiovascular autonomic function but not somatosensory nerve function and structure in overweight men with type 2 diabetes

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider