METABOLIC STUDIES WITH A NEW SERIES OF 1,4-DIENE STEROIDS. II. EFFECTS IN NORMAL SUBJECTS OF PREDNISONE, PREDNISOLONE, AND 9α-FLUOROPREDNISOLONE*

1,2-Dehydrogenation of 21-carbon steroids pos- sessing an oxygen function at carbons 11, 17 and 21 (cortisone and cortisol) results in an enhance- ment of anti-anabolic or catabolic and anti-inflam- matory properties in Addisonian subjects (2).