Key result
Each additional high-risk angle in carotid web angioarchitecture was associated with a significantly increased odds of stroke (OR 5.91), with patients having 2 or more high-risk angles showing an 83.4% predicted probability of stroke.
Why the study?
To validate a previously described carotid web risk stratification assessment in a larger cohort including patients with incidentally found asymptomatic carotid webs.
Does the number of high-risk carotid web angioarchitectural parameters predict stroke risk in patients with carotid webs?
Observational (n=35)
No
Does the number of high-risk carotid web angioarchitectural parameters predict stroke risk in patients with carotid webs?
The presence of two or more high-risk geometric parameters in carotid webs is associated with an 83.4% probability of stroke, which may help select asymptomatic patients for prophylactic intervention.
Validates CW risk stratification in larger asymptomatic cohort; leaves open whether it guides intervention decisions.
Objective To validate the carotid web (CW) risk stratification assessment described in our previous work with a larger cohort of patients with incidentally found asymptomatic CWs. Methods A retrospective analysis of our electronic medical record database identified all patients with a diagnosis of CW from 2017-2024 at our institution. We included symptomatic patients and those with asymptomatic carotid webs, meaning patients with incidentally found webs and no history of stroke or transient ischemic attack (TIA). Patient charts were reviewed for demographics, imaging, comorbidities, hospital course, and incidence of stroke after diagnosis of an asymptomatic carotid web. All angles were measured as described in our previous work on a sagittal reconstruction of CTA imaging of the neck in which the common carotid artery (CCA), external carotid artery (ECA), and ICA could be well visualized, along with the CW itself. A standard logistic regression was performed to evaluate the association between the number of high-risk angles and stroke risk. Results 26 asymptomatic and nine symptomatic patients were identified. Patients were categorized as having 0, 1, or 2+ high-risk angle values. Patients with more high-risk angles had a markedly higher risk of stroke (OR = 5.91, 95% CI: [4.25, 8.24]). The probability of stroke increased with the number of high-risk angles: patients with 2+ high-risk angles (83.4%) had the highest stroke probability compared to those with 0 (2.8%) or 1 (27.7%) high-risk angles. In the asymptomatic cohort, mean angles all fell below the high-risk threshold values. In the symptomatic cohort, mean angles were above the high-risk threshold values, whereas the mean CPT (53.6°) angle fell below the cut-off value for designation as a high-risk angle. Conclusions Given the successful stratification of CWs into high and low-risk groups in this study, the utilization of geometric CW parameters may play a crucial role in improvement of patient selection for intervention in patients with an incidental diagnosis of CW.
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Negash et al. (2024) conducted an observational in Carotid Web (n=35). High-risk carotid web angioarchitectural angles vs. Fewer or zero high-risk angles was evaluated on Stroke occurrence (OR 5.91, 95% CI 4.25-8.24). Each additional high-risk angle in carotid web angioarchitecture was associated with a significantly increased odds of stroke (OR 5.91), with patients having 2 or more high-risk angles showing an 83.4% predicted probability of stroke.
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