Key result
Liver transplantation followed by everolimus immunosuppression in a young woman with hepatic angiosarcoma resulted in stable physical condition for over two years despite local recurrence at 10 months.
Why the study?
Can everolimus be used as an immunosuppressive agent after liver transplantation for atypical malignancies like angiosarcoma?
Case Report (n=1)
Can everolimus be used as an immunosuppressive agent after liver transplantation for atypical malignancies like angiosarcoma?
Everolimus, a proliferation signal inhibitor, may have potential use as an immunosuppressive agent after liver transplantation for atypical malignancies like angiosarcoma.
Primary sarcomas of the liver are rare tumors and their diagnosis is difficult to assess, particularly on percutaneous liver biopsy. Epithelioid hemangioendothelioma (EHE) is an infrequent indication for liver transplantation, and angiosarcoma (AS) is a widely recognized contraindication because of its poor prognosis. We report the case of a young woman who underwent liver transplantation (LT) for an infiltrative hepatic tumor with several features suggestive of EHE, although the analysis of the native liver revealed AS. Everolimus was used as the main immunosuppressive drug. More than two years after LT, her physical condition remained stable despite a local recurrence at 10 months. In this setting, the ranking of new immunosuppressive agents belonging to the family of the proliferation signal inhibitors will need to be precise, but their intrinsic properties suggest a potential use in treatments after LT for atypical malignancies.
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Bismuth et al. (2009) conducted a case report in Primary sarcoma of the liver (angiosarcoma) (n=1). Liver transplantation and Everolimus was evaluated on Clinical outcome. Liver transplantation followed by everolimus immunosuppression in a young woman with hepatic angiosarcoma resulted in stable physical condition for over two years despite local recurrence at 10 months.
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