High ionic strength and low pH detain activated skinned rabbit skeletal muscle crossbridges in a low force state.
Population
Skinned rabbit skeletal muscle
Comparison
Varying pH and ionic strength vs Baseline conditions
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Requires validation in cardiac models before any clinical consideration; leaves open whether similar cross-bridge effects occur in myocardium.
Structured PICO
P
Population
Skinned rabbit skeletal muscle
I
Intervention
Varying pH (decreasing from 7.35 to 6.35) and ionic strength (raising from 125 to 360 mM)
C
Comparator
Baseline conditions (pH 7.35, ionic strength 125 mM)
O
Outcome
Force-velocity relations and tension transients (isometric force, sarcomere stiffness, maximum shortening velocity)surrogate
Low pH and high ionic strength inhibit the movement of crossbridges into the force-generating parts of their cycle in skeletal muscle.
Cite This Study
Seow et al. (1993) studied this question.