Eicosanoids are well known potent signaling mediators generated by cyclooxygenases (COXs), lipoxygenases (LOXs), and cytochrome P450 (CYP) enzymes in immune cells, platelets, and inflammatory activated tissues. As free acids, they signal by binding to G protein-coupled receptors following secretion from their cell of origin. For many years, it has been known that when added to cells, exogenous eicosanoids can be incorporated into more complex lipids, including phospholipids (PLs). However until recently this was considered little more than an epiphenomenon.
No takes yet. Share an insight, caveat, or question.
O’Donnell et al. (2017) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: