Key result
Women 15-25 years following a pregnancy complicated by pre-eclampsia demonstrated impaired microvascular function, suggesting a shared mechanism with coronary heart disease.
Observational
Pregnancies complicated by pre-eclampsia may identify women at long-term risk for vascular disease, offering a window for early lifestyle and risk factor modification.
May support vascular risk monitoring after pre-eclampsia; leaves open whether early intervention alters long-term outcomes.
Epidemiological studies have recently demonstrated a relationship between pre-eclampsia and coronary heart disease. Insulin resistance has been implicated as a common factor. We have demonstrated, for the first time, using laser Doppler imaging in vivo, impaired microvascular function in women 15-25 years following a pregnancy complicated by pre-eclampsia. Thus, microvascular dysfunction, which is associated with insulin resistance, may be a predisposing vascular mechanism for both coronary heart disease and pre-eclampsia. Pregnancies complicated by pre-eclampsia may identify women at risk of vascular disease in later life and may provide the opportunity for lifestyle and risk factor modification to alter maternal vascular disease risk.
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Ramsay et al. (2003) conducted an observational in Pre-eclampsia. Pregnancy complicated by pre-eclampsia was evaluated on Microvascular function. Women 15-25 years following a pregnancy complicated by pre-eclampsia demonstrated impaired microvascular function, suggesting a shared mechanism with coronary heart disease.
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