The successful use of amphotericin B followed by oral posaconazole in a rare case of invasive fungal sinusitis caused by co-infection with mucormycosis and aspergillus

Sharana Mahomed; Sujith Basanth; Koleka Mlisana

doi:10.1016/j.idcr.2015.10.001

January 1, 2015IDCasesOpen Access

The successful use of amphotericin B followed by oral posaconazole in a rare case of invasive fungal sinusitis caused by co-infection with mucormycosis and aspergillus

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Key Points

Describe the clinical presentation, management, and outcomes of a rare oro-rhinocerebral co-infection involving mucormycosis and aspergillus.
Case report of a 54-year-old insulin-dependent diabetic patient presenting with invasive oro-rhinocerebral disease (N=1).
Intervention comprised initial treatment with parenteral amphotericin B followed by maintenance therapy with oral posaconazole.
Sequential treatment with parenteral amphotericin B followed by oral posaconazole successfully eradicated the invasive co-infection.
The patient developed severe, irreversible morbidity consisting of unilateral blindness in the right eye and multiple cranial nerve palsies.

Implication

Case report shows successful eradication of dual fungal sinusitis in a diabetic patient, highlighting risk of permanent neurological deficits.

Abstract

We report on an unusual case of oro-rhinocerebral disease caused by mucormycosis and aspergillus co-infection in a 54-year-old insulin dependent diabetic patient. Although she was successfully treated with parenteral amphotericin B followed by oral posaconazole, she was left with irreversible blindness of the right eye and multiple cranial nerve palsies.

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Cite This Study

Mahomed et al. (2015) studied this question.

synapsesocial.com/papers/6a7944473b1c66cefb5af34f https://doi.org/10.1016/j.idcr.2015.10.001

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The successful use of amphotericin B followed by oral posaconazole in a rare case of invasive fungal sinusitis caused by co-infection with mucormycosis and aspergillus

Key Points

Implication

Abstract

Discussion

Cite This Study

The successful use of amphotericin B followed by oral posaconazole in a rare case of invasive fungal sinusitis caused by co-infection with mucormycosis and aspergillus

Key Points

Implication

Abstract

Discussion

Cite This Study

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