Prognostic Power of Pulmonary Arterial Compliance Is Boosted by a Hemodynamic Unloading Test With Glyceryl Trinitrate in Heart Failure Patients With Post-capillary Pulmonary Hypertension

Figures

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  Figure 1. Key hemodynamic parameters at baseline and after glyceryl trinitrate (GTN) application in all patients, in patients who did not reach the endpoint transplant/LVAD free survival (EP-), and in patients reaching the endpoint (EP+). PP, pulse pressure; SV, stroke volume; PAC, pulmonary arterial compliance; BL, baseline. ****P <0.00001.

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  Figure 2. Forest plot of different hemodynamic variables and their impact on prognosis. PAC, pulmonary arterial compliance; CpcPH, combined post- and pre-capillary pulmonary hypertension (“yes,” if pulmonary vascular resistance >3 wood units and/or diastolic pulmonary gradient ≥7 mmHg); GTN, glyceryl trinitrate; Ea, pulmonary effective arterial elastance (calculated); TPR, total pulmonary resistance.

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  Figure 3. AUC of ROC analysis for prediction of survival. Left panel: variables of the MAGGIC score; right panel: MAGGIC variables and PAC-GTN.

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  Figure 4. Kaplan-Meier analysis of key variables CpcPH, baseline PAC, and PAC-GTN. CpcPH, combined post- and pre-capillary pulmonary hypertension (“yes,” if pulmonary vascular resistance >3 wood units and/or diastolic pulmonary gradient ≥7 mmHg); PAC, pulmonary arterial compliance; GTN, glyceryl trinitrate.