Key result
Multiple genetic polymorphisms, particularly in genes encoding PDE4D and ALOX5AP, are associated with an increased risk of ischemic stroke, although results often vary across different ethnic populations.
This review highlights the role of genetic factors, particularly PDE4D and ALOX5AP, in the risk of ischemic stroke, which may have implications for early diagnosis and prevention.
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Associations of PDE4D and ALOX5AP variants with ischemic stroke risk remain hypothesis-generating; leaves open clinical utility pending replication across populations.
Advances in the Genetic Basis of Ischemic Stroke As one of the leading causes of death within both the developed and developing world, stroke is a world-wide problem. About 80% of strokes are ischemic. It is caused by multiple genetic factors, environmental factors, and interactions among these factors. There is a long list of candidate genes that have been studied for a possible association with ischemic stroke. Among the most widely investigated genes are those involved in haemostasis, inflammation, nitric oxide production, homocysteine and lipid metabolism, renin-angiotensin-aldosterone system. Combined link-age/association studies have demonstrated that genes encoding PDE4D and ALOX5AP confer risk for stroke. We review the studies of these genes which may have potential application on the early diagnosis, prevention and treatment ischemic stroke patients.
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Stanković et al. (2008) conducted a review in Ischemic stroke. Genetic polymorphisms vs. Wild-type or non-carriers was evaluated. Multiple genetic polymorphisms, particularly in genes encoding PDE4D and ALOX5AP, are associated with an increased risk of ischemic stroke, although results often vary across different ethnic populations.
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