Answers are grounded in this paper and cite their sources.
A patient with cutaneous necrotizing vasculitis had chronic urticaria associated with multiple system involvement including arthralgias, glomerulonephritis, myositis, pseudotumor cerebri, and adenopathy. Persistent hypocomplementemia is noted with classic pathway activation. The syndrome recognized in this patient and those few individuals reported previously seems to constitute a distinct category of collagen-vascular disease.
No takes yet. Share an insight, caveat, or question.
Peter U. Feig (1976) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: